MolNFT v1 · #161625 · protein
Crystal structure of yeast 14-3-3 protein (BMH1) from saccharomyces cerevisiae with the NHA1P (yeast NA+/H+ antiporter) 14-3-3 binding motif SER481
6QK8 · Protein BMH1: “Crystal structure of yeast 14-3-3 protein (BMH1) from saccharomyces cerevisiae with the NHA1P (yeast NA+/H+…”. X-ray diffraction, 9 pockets (best druggability 0.85). MolNFT v1 #161625 on GenesisL1: 3D structure…
- PDB
- 6QK8
- Type
- protein
- Length
- 909 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein BMH1; NA(+)/H(+) antiporter
- UniProt
- P29311, Q99271
- Pockets
- 9 · best druggability 0.85
Structure
x-ray diffraction · 6 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein BMH1 | protein | 226 | 81% helix, 0% strand | P29311 |
| B | Protein BMH1 | protein | 225 | 82% helix, 0% strand | P29311 |
| C | Protein BMH1 | protein | 213 | 81% helix, 0% strand | P29311 |
| D | Protein BMH1 | protein | 215 | 82% helix, 0% strand | P29311 |
| E, F, H | NA(+)/H(+) antiporter | protein | 8 | 0% helix, 0% strand | Q99271 |
| G | NA(+)/H(+) antiporter | protein | 6 | 0% helix, 0% strand | Q99271 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1111 | 0.85 | 0.86 | 100 | empty |
| 2 | 1160 | 0.84 | 0.85 | 113 | empty |
| 3 | 156 | 0.67 | 0.87 | 27 | empty |
| 4 | 89 | 0.55 | 0.85 | 16 | empty |
| 5 | 129 | 0.52 | 0.80 | 23 | empty |
Interfaces
14 interfaces between chains.
- A–C · 1047 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 1034 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 725 Ų buried · 2 hydrogen bonds · protein-protein
- A–E · 712 Ų buried · 15 hydrogen bonds · protein-protein
- B–H · 613 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (phosphorylation).
Compared structures
- 6QK8 · Crystal structure of yeast 14-3-3 protein (Bmh1) from Saccharomyces cerevisiae with the… · the same entry in another collection · chain H against H, TM-score 1.00
- P29311 · AlphaFold monomer V2.0 prediction for protein BMH1 (P29311) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29311
- Every structure of UniProt Q99271
- Elsewhere: RCSB PDB 6QK8 · PDBe 6QK8 · UniProt P29311 · UniProt Q99271
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