MolNFT v1 · #161588 · protein
Crystal structure of the C. thermophilum condensin YCS4-BRN1 subcomplex bound to the SMC4 ATPase head in complex with the C- terminal domain of BRN1
6QJ4 · Condensin complex subunit 1,CONDENSIN complex subunit 1…: “Crystal structure of the C. thermophilum condensin YCS4-BRN1 subcomplex bound to the SMC4 ATPase head in…”. X-ray diffraction, 20 pockets (best druggability 0.87). MolNFT v1…
- PDB
- 6QJ4
- Type
- protein
- Length
- 1,412 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Condensin complex subunit 1,CONDENSIN complex subunit 1, condensin complex subunit 1…
- UniProt
- G0SB82, G0SBJ6, G0S2G2
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 5 distinct chains · 56% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Condensin complex subunit 1,CONDENSIN complex subunit 1, condensin complex subunit 1 | protein | 963 | 66% helix, 0% strand | G0SB82 |
| B | Condensin complex subunit 2 | protein | 50 | 22% helix, 4% strand | G0SBJ6 |
| C | Uncharacterized PROTEIN,UNCHARACTERIZED protein | protein | 306 | 35% helix, 25% strand | G0S2G2 |
| D | BRN1 | protein | 22 | 0% helix, 0% strand | — |
| E | Condensin complex subunit 2 | protein | 71 | 51% helix, 6% strand | G0SBJ6 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1084 | 0.87 | 0.87 | 100 | empty |
| 2 | 922 | 0.86 | 0.87 | 121 | empty |
| 3 | 1024 | 0.85 | 0.85 | 96 | empty |
| 4 | 768 | 0.83 | 0.85 | 84 | empty |
| 5 | 369 | 0.80 | 0.90 | 57 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2080 Ų buried · 24 hydrogen bonds · protein-protein
- C–E · 905 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 521 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 295 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6QJ4 · Crystal structure of the C. thermophilum condensin Ycs4-Brn1 subcomplex bound to the Smc4… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SB82
- Every structure of UniProt G0SBJ6
- Every structure of UniProt G0S2G2
- Elsewhere: RCSB PDB 6QJ4 · PDBe 6QJ4 · UniProt G0SB82 · UniProt G0SBJ6 · UniProt G0S2G2
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