MolNFT v1 · #161535 · protein
Structure of the cap-binding domain of rift valley fever virus L protein
6QHG · Polymerase: “Structure of the cap-binding domain of rift valley fever virus L protein”. X-ray diffraction, 2 ligands (MGT, PO4), 1 pocket (best druggability 0.42). MolNFT v1 #161535 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6QHG
- Type
- protein
- Length
- 236 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase
- UniProt
- F4ZDJ0
- Ligands
- MGT, PO4
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase | protein | 119 | 13% helix, 45% strand | F4ZDJ0 |
| B | Polymerase | protein | 117 | 15% helix, 47% strand | F4ZDJ0 |
Ligands and binding sites
- MGT · 7N-methyl-8-hydroguanosine-5'-triphosphate · ligand · 2 copies · chains A, B
- PO4 · Phosphate ion · ion · chains B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.42 | 0.75 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 481 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 6QHG · Structure of the cap-binding domain of Rift Valley Fever virus L protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F4ZDJ0
- Elsewhere: RCSB PDB 6QHG · PDBe 6QHG · UniProt F4ZDJ0
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