Structure of human BCL-2 in complex with abt-263

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).

Ligands and binding sites

• 1XJ · 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6QGH · Structure of human Bcl-2 in complex with ABT-263 · the same entry in another collection · chain A against A, TM-score 1.00
• P10415 · AlphaFold monomer V2.0 prediction for apoptosis regulator BCL-2 (P10415) · a predicted model of the same protein · chain A against A, TM-score 0.88
• Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P10415
• Every structure of UniProt Q07817
• Elsewhere: RCSB PDB 6QGH · PDBe 6QGH · UniProt P10415 · UniProt Q07817