Structure of human BCL-2 in complex with analogue of abt-737

Structure

x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).

Ligands and binding sites

• J1H · [(3~{R})-3-[[4-[[4-[4-[[2-(4-chlorophenyl) phenyl]methyl]piperazin-1-yl]phenyl]carbonylsulfamoyl]-2-nitro-phenyl]amino]-4-phenylsulfanyl-butyl]-(2-hydroxy-2-oxoethyl)-dimethyl-azanium · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 6QGG · Structure of human Bcl-2 in complex with analogue of ABT-737 · the same entry in another collection · chain A against A, TM-score 1.00
• P10415 · AlphaFold monomer V2.0 prediction for apoptosis regulator BCL-2 (P10415) · a predicted model of the same protein · chain A against A, TM-score 0.97
• Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P10415
• Every structure of UniProt Q07817
• Elsewhere: RCSB PDB 6QGG · PDBe 6QGG · UniProt P10415 · UniProt Q07817