MolNFT v1 · #161460 · protein
Structure of an anti-MCL1 scfv
6QF9: “Structure of an anti-MCL1 scfv”. X-ray diffraction, 6 pockets (best druggability 0.75). MolNFT v1 #161460 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6QF9
- Type
- protein
- Length
- 477 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Scfv
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Scfv | protein | 238 | 6% helix, 49% strand | — |
| B | Scfv | protein | 239 | 5% helix, 49% strand | — |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1061 | 0.75 | 0.78 | 117 | empty |
| 2 | 125 | 0.40 | 0.75 | 24 | empty |
| 3 | 70 | 0.36 | 0.77 | 11 | empty |
| 4 | 93 | 0.36 | 0.75 | 19 | empty |
| 5 | 65 | 0.33 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 610 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6QF9 · Structure of an anti-Mcl1 scFv · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6QF9 · PDBe 6QF9
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