MolNFT v1 · #161407 · protein
Molecular features of the unc-45 chaperone critical for binding and folding muscle myosin
6QDK · Unc-45,UNC-45: “Molecular features of the unc-45 chaperone critical for binding and folding muscle myosin”. X-ray diffraction, 12 pockets (best druggability 0.78). MolNFT v1 #161407 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6QDK
- Type
- protein
- Length
- 882 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unc-45,UNC-45
- UniProt
- G5EG62
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unc-45,UNC-45 | protein | 882 | 67% helix, 0% strand | G5EG62 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1022 | 0.78 | 0.80 | 114 | empty |
| 2 | 301 | 0.75 | 0.87 | 34 | empty |
| 3 | 339 | 0.68 | 0.82 | 41 | empty |
| 4 | 172 | 0.63 | 0.84 | 30 | empty |
| 5 | 63 | 0.58 | 0.89 | 17 | empty |
Modifications
Observed in the structure: 25 modified (engineered).
Compared structures
- 6QDK · Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G5EG62
- Elsewhere: RCSB PDB 6QDK · PDBe 6QDK · UniProt G5EG62
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