MolNFT v1 · #161381 · protein

Crystal structure of a Fab portion of the anti ebov 3T0331 antibody

6QCU · Light chain: “Crystal structure of a Fab portion of the anti ebov 3T0331 antibody”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.59). MolNFT v1 #161381 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6QCU
Type: protein
Length: 433 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Light chain; Heavy chain
Ligands: SO4
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Light chain	protein	212	7% helix, 51% strand	—
H	Heavy chain	protein	221	10% helix, 50% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	521	0.59	0.74	63	SO4
2	233	0.50	0.75	35	empty
3	78	0.33	0.75	22	empty

Interfaces

1 interface between chains.

L–H · 1703 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6QCU · Crystal structure of a Fab portion of the anti EBOV 3T0331 antibody · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6QCU · PDBe 6QCU

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