MolNFT v1 · #161182 · protein

Structure of the copper storage protein, ccsp, from streptomyces lividans loaded with 10 copper equivalents

6Q6B · Cytosolic copper storage protein: “Structure of the copper storage protein, ccsp, from streptomyces lividans loaded with 10 copper equivalents”. X-ray diffraction, 2 ligands (CU1, CU), 6 pockets (best druggability 0.58). MolNFT v1…

PDB: 6Q6B
Type: protein
Length: 483 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytosolic copper storage protein
UniProt: Q9X8F4
Ligands: CU1, CU
Pockets: 6 · best druggability 0.58

Structure

x-ray diffraction · 4 distinct chains · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Cytosolic copper storage protein	protein	118	84% helix, 0% strand	Q9X8F4
C	Cytosolic copper storage protein	protein	116	84% helix, 0% strand	Q9X8F4
A	Cytosolic copper storage protein	protein	132	79% helix, 0% strand	Q9X8F4
D	Cytosolic copper storage protein	protein	117	83% helix, 0% strand	Q9X8F4

Ligands and binding sites

CU1 · Copper (I) ion · metal · 59 copies · chains B, C, A, D
CU · Copper (II) ion · metal · 5 copies · chains B, A, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.58	0.79	37	empty
2	86	0.55	0.86	21	empty
3	158	0.49	0.78	23	empty
4	93	0.36	0.75	16	empty
5	64	0.32	0.75	15	empty

Interfaces

5 interfaces between chains.

C–A · 1070 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 695 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 524 Å² buried · 9 hydrogen bonds · protein-protein
B–A · 429 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 249 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6Q6B · Structure of the copper storage protein, Ccsp, from Streptomyces lividans loaded with 10… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X8F4
Elsewhere: RCSB PDB 6Q6B · PDBe 6Q6B · UniProt Q9X8F4

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