MolNFT v1 · #161169 · protein

Crystal structure of mycolicibacterium hassiacum glucosylglycerate hydrolase (mhggh) - apo form

6Q5T: “Crystal structure of mycolicibacterium hassiacum glucosylglycerate hydrolase (mhggh) - apo form”. X-ray diffraction, 9 pockets (best druggability 0.68). MolNFT v1 #161169 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6Q5T
Type: protein
Length: 879 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hydrolase
UniProt: K5BDL0
Pockets: 9 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hydrolase	protein	437	48% helix, 6% strand	K5BDL0
B	Hydrolase	protein	442	48% helix, 6% strand	K5BDL0

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.68	0.88	30	empty
2	124	0.68	0.89	30	empty
3	381	0.60	0.76	51	empty
4	148	0.40	0.74	26	empty
5	52	0.35	0.79	14	empty

Interfaces

1 interface between chains.

A–B · 1121 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

6Q5T · Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH)… · the same entry in another collection · chain A against A, TM-score 1.00
K5BDL0 · AlphaFold monomer V2.0 prediction for glucosylglycerate hydrolase (K5BDL0) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt K5BDL0
Elsewhere: RCSB PDB 6Q5T · PDBe 6Q5T · UniProt K5BDL0

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