MolNFT v1 · #161152 · protein
Crystal structure of cryptosporidium hominis CPSF3 in the apo form
6Q5A · Cleavage and polyadenylation specificity factor 3: “Crystal structure of cryptosporidium hominis CPSF3 in the apo form”. X-ray diffraction, 2 ligands (ZN, MG), 4 pockets (best druggability 0.83). MolNFT v1 #161152 on GenesisL1: 3D…
- PDB
- 6Q5A
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cleavage and polyadenylation specificity factor 3
- UniProt
- A0A0S4TJL4
- Ligands
- ZN, MG
- Pockets
- 4 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cleavage and polyadenylation specificity factor 3 | protein | 461 | 32% helix, 21% strand | A0A0S4TJL4 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
- MG · Magnesium ion · metal · chains A
- IPA · Isopropyl alcohol · additive · 3 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 242 | 0.83 | 0.95 | 39 | MG |
| 2 | 137 | 0.42 | 0.75 | 21 | empty |
| 3 | 65 | 0.40 | 0.80 | 23 | empty |
| 4 | 54 | 0.25 | 0.73 | 19 | empty |
Compared structures
- 6Q5A · Crystal structure of Cryptosporidium hominis CPSF3 in the apo form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0S4TJL4
- Elsewhere: RCSB PDB 6Q5A · PDBe 6Q5A · UniProt A0A0S4TJL4
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