MolNFT v1 · #161140 · protein
Structure of mpt-1, a GDP-man-dependent mannosyltransferase from leishmania mexicana
6Q4W · Lmxm mpt-1: “Structure of mpt-1, a GDP-man-dependent mannosyltransferase from leishmania mexicana”. X-ray diffraction, 9 pockets (best druggability 0.60). MolNFT v1 #161140 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6Q4W
- Type
- protein
- Length
- 618 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lmxm mpt-1
- UniProt
- E9AND7
- Pockets
- 9 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lmxm mpt-1 | protein | 311 | 10% helix, 51% strand | E9AND7 |
| B | Lmxm mpt-1 | protein | 307 | 9% helix, 52% strand | E9AND7 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 211 | 0.60 | 0.81 | 29 | empty |
| 2 | 269 | 0.59 | 0.79 | 34 | empty |
| 3 | 302 | 0.59 | 0.77 | 36 | empty |
| 4 | 199 | 0.58 | 0.80 | 28 | empty |
| 5 | 90 | 0.50 | 0.82 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1299 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 6Q4W · Structure of MPT-1, a GDP-Man-dependent mannosyltransferase from Leishmania mexicana · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9AND7
- Elsewhere: RCSB PDB 6Q4W · PDBe 6Q4W · UniProt E9AND7
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