MolNFT v1 · #16113 · protein
18-K C-terminally trunucated small subunit of calpain
1NP8 · Calcium-dependent protease, small subunit: “18-K C-terminally trunucated small subunit of calpain”. X-ray diffraction, 1 ligand (CD), 2 pockets (best druggability 0.53). MolNFT v1 #16113 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1NP8
- Type
- protein
- Length
- 298 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-dependent protease, small subunit
- UniProt
- Q64537
- Ligands
- CD
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Calcium-dependent protease, small subunit | protein | 149 | 65% helix, 3% strand | Q64537 |
Ligands and binding sites
- CD · Cadmium ion · metal · 13 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 270 | 0.53 | 0.75 | 47 | empty |
| 2 | 214 | 0.49 | 0.76 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 817 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q64537
- Elsewhere: RCSB PDB 1NP8 · PDBe 1NP8 · UniProt Q64537
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