MolNFT v1 · #161031 · protein

Inferred intermediate I-7 of the human antibody lineage 652

6Q1K · Fab heavy chain: “Inferred intermediate I-7 of the human antibody lineage 652”. X-ray diffraction, 3 pockets (best druggability 0.58). MolNFT v1 #161031 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6Q1K
Type: protein
Length: 441 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab heavy chain; Fab lambda light chain
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab heavy chain	protein	231	6% helix, 48% strand	—
L	Fab lambda light chain	protein	210	8% helix, 50% strand	—

Ligands and binding sites

GOL · Glycerol · additive · chains L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	480	0.58	0.74	56	empty
2	117	0.43	0.77	26	empty
3	61	0.32	0.76	17	empty

Interfaces

1 interface between chains.

H–L · 1889 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6Q1K · Inferred intermediate I-7 of the human antibody lineage 652 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6Q1K · PDBe 6Q1K

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