MolNFT v1 · #161030 · protein

Antibody H2227 from the human antibody lineage 652

6Q1J · Fab heavy chain: “Antibody H2227 from the human antibody lineage 652”. X-ray diffraction, 2 pockets (best druggability 0.66). MolNFT v1 #161030 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6Q1J
Type: protein
Length: 443 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab heavy chain; Fab lambda light chain
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab heavy chain	protein	231	7% helix, 49% strand	—
L	Fab lambda light chain	protein	212	8% helix, 51% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	765	0.66	0.74	88	empty
2	74	0.36	0.77	20	empty

Interfaces

1 interface between chains.

H–L · 2125 Å² buried · 26 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6Q1J · Antibody H2227 from the human antibody lineage 652 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6Q1J · PDBe 6Q1J

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