MolNFT v1 · #161021 · protein

Inferred intermediate (I-6) of the human antibody lineage 652

6Q19 · Fab lambda chain: “Inferred intermediate (I-6) of the human antibody lineage 652”. X-ray diffraction, 3 pockets (best druggability 0.62). MolNFT v1 #161021 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6Q19
Type: protein
Length: 445 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab lambda chain; Fab heavy chain
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Fab lambda chain	protein	212	8% helix, 50% strand	—
H	Fab heavy chain	protein	233	6% helix, 47% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	564	0.62	0.74	58	empty
2	156	0.45	0.76	26	empty
3	92	0.36	0.76	22	empty

Interfaces

1 interface between chains.

L–H · 1830 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6Q19 · Inferred intermediate (I-6) of the human antibody lineage 652 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6Q19 · PDBe 6Q19

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