MolNFT v1 · #161012 · protein
The cryo-EM structure of the snx-bar MVP1 tetramer
6Q0X · Sorting nexin MVP1: “The cryo-EM structure of the snx-bar MVP1 tetramer”. Electron microscopy, 19 pockets (best druggability 0.84). MolNFT v1 #161012 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6Q0X
- Type
- protein
- Length
- 1,492 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sorting nexin MVP1
- UniProt
- P40959
- Pockets
- 19 · best druggability 0.84
Structure
electron microscopy · 1 distinct chain · 69% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Sorting nexin MVP1 | protein | 373 | 69% helix, 4% strand | P40959 |
Pockets
19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 732 | 0.84 | 0.87 | 99 | empty |
| 2 | 929 | 0.83 | 0.85 | 94 | empty |
| 3 | 1030 | 0.82 | 0.83 | 126 | empty |
| 4 | 814 | 0.81 | 0.84 | 89 | empty |
| 5 | 55 | 0.64 | 0.94 | 18 | empty |
Interfaces
6 interfaces between chains.
- A–B · 3194 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 3185 Ų buried · 27 hydrogen bonds · protein-protein
- A–D · 1103 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 1092 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 292 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40959
- Elsewhere: RCSB PDB 6Q0X · PDBe 6Q0X · UniProt P40959
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