Hydrocarbon-stapled paxillin peptide bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase (fak)

Structure

x-ray diffraction · 2 distinct chains · 84% helix, 0% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains B
• 2JN · 2-methyl-D-norleucine · ligand · chains B
• ZN · Zinc ion · metal · chains A
• NH2 · Amino group · ion · chains B
• CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 634 Ų buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 covalent, 1 modified (covalent ligand, nonstandard).

Compared structures

• 6PW8 · Hydrocarbon-Stapled Paxillin Peptide Bound to the Focal Adhesion Targeting (FAT) Domain… · the same entry in another collection · chain A against A, TM-score 1.00
• Q05397 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q05397) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q05397
• Elsewhere: RCSB PDB 6PW8 · PDBe 6PW8 · UniProt Q05397