MolNFT v1 · #16080 · protein

Knob domain from adenovirus serotype 12

1NOB · Protein (fiber knob protein): “Knob domain from adenovirus serotype 12”. X-ray diffraction, 12 pockets (best druggability 0.85). MolNFT v1 #16080 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1NOB
Type: protein
Length: 1,110 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (fiber knob protein)
UniProt: P36711
Pockets: 12 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Protein (fiber knob protein)	protein	185	10% helix, 42% strand	P36711

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	279	0.85	0.96	47	empty
2	326	0.85	0.95	47	empty
3	681	0.73	0.80	60	empty
4	87	0.44	0.80	18	empty
5	94	0.42	0.78	20	empty

Interfaces

8 interfaces between chains.

D–F · 1086 Å² buried · 19 hydrogen bonds · protein-protein
A–B · 1055 Å² buried · 15 hydrogen bonds · protein-protein
A–C · 1050 Å² buried · 18 hydrogen bonds · protein-protein
E–F · 1036 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 1035 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

1NOB · Knob domain from adenovirus serotype 12 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P36711
Elsewhere: RCSB PDB 1NOB · PDBe 1NOB · UniProt P36711

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