MolNFT v1 · #160398 · protein
Time-resolved structural snapshot of proteolysis by glpg inside the membrane
6PJ8 · Rhomboid protease glpg: “Time-resolved structural snapshot of proteolysis by glpg inside the membrane”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #160398 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6PJ8
- Type
- protein
- Length
- 186 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rhomboid protease glpg; Peptide aldehyde inhibitor
- EC
- 3.4.21.105
- UniProt
- A0A0J2E248
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rhomboid protease glpg (EC 3.4.21.105) | protein | 181 | 78% helix, 2% strand | A0A0J2E248 |
| B | Peptide aldehyde inhibitor | protein | 5 | 0% helix, 40% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.46 | 0.81 | 16 | empty |
| 2 | 59 | 0.32 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 477 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6PJ8 · Time-resolved structural snapshot of proteolysis by GlpG inside the membrane · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0J2E248
- Elsewhere: RCSB PDB 6PJ8 · PDBe 6PJ8 · UniProt A0A0J2E248
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