MolNFT v1 · #160335 · protein
PFS25 in complex with the human transmission blocking antibody 2587
6PHF · 2587 antibody Fab, heavy chain: “PFS25 in complex with the human transmission blocking antibody 2587”. X-ray diffraction, 17 pockets (best druggability 0.86). MolNFT v1 #160335 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6PHF
- Type
- protein
- Length
- 1,177 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2587 antibody Fab, heavy chain; 25 kda ookinete surface antigen; 2587 antibody Fab, light…
- UniProt
- P13829
- Pockets
- 17 · best druggability 0.86
Structure
x-ray diffraction · 6 distinct chains · 7% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2587 antibody Fab, heavy chain | protein | 215 | 7% helix, 53% strand | — |
| G | 25 kda ookinete surface antigen | protein | 161 | 4% helix, 43% strand | P13829 |
| B | 2587 antibody Fab, light chain | protein | 207 | 8% helix, 50% strand | — |
| C | 2587 antibody Fab, heavy chain | protein | 216 | 8% helix, 51% strand | — |
| E | 25 kda ookinete surface antigen | protein | 170 | 4% helix, 44% strand | P13829 |
| D | 2587 antibody Fab, light chain | protein | 208 | 8% helix, 50% strand | — |
Pockets
17 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 604 | 0.86 | 0.91 | 69 | empty |
| 2 | 831 | 0.84 | 0.86 | 130 | empty |
| 3 | 385 | 0.62 | 0.77 | 40 | empty |
| 4 | 387 | 0.61 | 0.76 | 42 | empty |
| 5 | 90 | 0.58 | 0.87 | 20 | empty |
Interfaces
10 interfaces between chains.
- C–D · 1741 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1657 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 594 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 592 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 495 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 30 disulfide (disulfide).
Compared structures
- 6PHF · Pfs25 in complex with the human transmission blocking antibody 2587 · the same entry in another collection · chain B against B, TM-score 1.00
- P13829 · AlphaFold monomer V2.0 prediction for 25 kda ookinete surface antigen (P13829) · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13829
- Elsewhere: RCSB PDB 6PHF · PDBe 6PHF · UniProt P13829
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.