MolNFT v1 · #160279 · protein

RSEGFP2 with a chlorinated chromophore in the fluorescent on-state in a contracted unit cell

6PFS · Green fluorescent protein: “RSEGFP2 with a chlorinated chromophore in the fluorescent on-state in a contracted unit cell”. X-ray diffraction, 2 ligands (OHD, SO4), 2 pockets (best druggability 0.74). MolNFT v1 #160279 on GenesisL1…

PDB: 6PFS
Type: protein
Length: 228 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Green fluorescent protein
Ligands: OHD, SO4
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Green fluorescent protein	protein	228	12% helix, 52% strand	—

Ligands and binding sites

OHD · {(4Z)-2-[(1S)-1-aminoethyl]-4-[(3-chloro-4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.74	0.96	25	OHD
2	57	0.39	0.81	15	empty

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

6PFS · rsEGFP2 with a chlorinated chromophore in the fluorescent on-state in a contracted unit… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6PFS · PDBe 6PFS

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