MolNFT v1 · #160256 · protein
Crystal structure of human thymidylate synthase delta (7-29) in complex with dump and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H- PYRROLO[2,3-D]PYRIMIDIN-5-YL)METHYL)BENZAMIDO)-4-METHOXYPHENYL)ACETIC acid
6PF5: “Crystal structure of human thymidylate synthase delta (7-29) in complex with dump and…”. X-ray diffraction, 2 ligands (UMP, OED). MolNFT v1 #160256 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6PF5
- Type
- protein
- Length
- 1,140 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P04818
- Ligands
- UMP, OED
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | — | protein | 285 | — | P04818 |
Ligands and binding sites
- UMP · 2'-deoxyuridine 5'-monophosphate · ligand · 4 copies · chains A, B, C, D
- OED · [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6PF5 · Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04818
- Elsewhere: RCSB PDB 6PF5 · PDBe 6PF5 · UniProt P04818
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