MolNFT v1 · #160181 · protein
Crystal structure of the bacterial cellulose synthase subunit G (bcsg) catalytic domain from escherichia COLI, selenomethionine variant
6PCZ · Cellulose biosynthesis protein bcsg: “Crystal structure of the bacterial cellulose synthase subunit G (bcsg) catalytic domain from escherichia…”. X-ray diffraction, 2 ligands (ZN, MG), 11 pockets (best druggability 0.72). MolNFT v1…
- PDB
- 6PCZ
- Type
- protein
- Length
- 727 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellulose biosynthesis protein bcsg
- UniProt
- P37659
- Ligands
- ZN, MG
- Pockets
- 11 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cellulose biosynthesis protein bcsg | protein | 363 | 32% helix, 21% strand | P37659 |
| B | Cellulose biosynthesis protein bcsg | protein | 364 | 32% helix, 20% strand | P37659 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 691 | 0.72 | 0.78 | 65 | empty |
| 2 | 130 | 0.57 | 0.83 | 25 | empty |
| 3 | 112 | 0.56 | 0.84 | 26 | empty |
| 4 | 99 | 0.54 | 0.84 | 29 | empty |
| 5 | 116 | 0.54 | 0.83 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 616 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 6PCZ · Crystal structure of the bacterial cellulose synthase subunit G (BcsG) catalytic domain… · the same entry in another collection · chain A against A, TM-score 1.00
- P37659 · AlphaFold monomer V2.0 prediction for cellulose biosynthesis protein bcsg (P37659) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37659
- Elsewhere: RCSB PDB 6PCZ · PDBe 6PCZ · UniProt P37659
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