MolNFT v1 · #160164 · protein

Human COA6: W59C mutant protein

6PCF · Cytochrome C oxidase assembly factor 6 homolog: “Human COA6: W59C mutant protein”. X-ray diffraction, 4 pockets (best druggability 0.76). MolNFT v1 #160164 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6PCF
Type: protein
Length: 243 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome C oxidase assembly factor 6 homolog
UniProt: Q5JTJ3
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · 4 distinct chains · 84% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Cytochrome C oxidase assembly factor 6 homolog	protein	65	85% helix, 0% strand	Q5JTJ3
C	Cytochrome C oxidase assembly factor 6 homolog	protein	56	84% helix, 0% strand	Q5JTJ3
A	Cytochrome C oxidase assembly factor 6 homolog	protein	58	83% helix, 0% strand	Q5JTJ3
D	Cytochrome C oxidase assembly factor 6 homolog	protein	64	83% helix, 0% strand	Q5JTJ3

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	854	0.76	0.80	62	empty
2	446	0.69	0.80	28	empty
3	217	0.54	0.77	26	empty
4	59	0.42	0.81	22	empty

Interfaces

5 interfaces between chains.

B–A · 671 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 482 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 469 Å² buried · 7 hydrogen bonds · protein-protein
B–D · 147 Å² buried · 1 hydrogen bond · protein-protein
C–D · 135 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

6PCF · Human Coa6: W59C mutant protein · the same entry in another collection · chain D against D, TM-score 1.00
Q5JTJ3 · AlphaFold monomer V2.0 prediction for cytochrome C oxidase assembly factor 6 homolog… · a predicted model of the same protein · chain D against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5JTJ3
Elsewhere: RCSB PDB 6PCF · PDBe 6PCF · UniProt Q5JTJ3

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