MolNFT v1 · #160005 · protein
Structure of the K. lactis CBF3 core
6P7V · CTF13: “Structure of the K. lactis CBF3 core”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #160005 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6P7V
- Type
- protein
- Length
- 1,384 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CTF13; SKP1; CEP3
- UniProt
- Q6CK37, O94228, Q6CRD4
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 4 distinct chains · 61% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | CTF13 | protein | 325 | 30% helix, 17% strand | Q6CK37 |
| D | SKP1 | protein | 126 | 56% helix, 13% strand | O94228 |
| B | CEP3 | protein | 476 | 71% helix, 0% strand | Q6CRD4 |
| A | CEP3 | protein | 457 | 73% helix, 0% strand | Q6CRD4 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 567 | 0.84 | 0.89 | 68 | empty |
| 2 | 992 | 0.84 | 0.84 | 102 | empty |
| 3 | 681 | 0.80 | 0.85 | 67 | empty |
| 4 | 344 | 0.80 | 0.89 | 63 | empty |
| 5 | 317 | 0.75 | 0.86 | 47 | empty |
Interfaces
4 interfaces between chains.
- B–A · 1496 Ų buried · 12 hydrogen bonds · protein-protein
- C–B · 1379 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 903 Ų buried · 6 hydrogen bonds · protein-protein
- D–B · 287 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6P7V · Structure of the K. lactis CBF3 core · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6CK37
- Every structure of UniProt O94228
- Every structure of UniProt Q6CRD4
- Elsewhere: RCSB PDB 6P7V · PDBe 6P7V · UniProt Q6CK37 · UniProt O94228 · UniProt Q6CRD4
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