MolNFT v1 · #159918 · protein
Crystal structure of the beta subunit of luteinizing hormone
6P57 · Lutropin subunit beta: “Crystal structure of the beta subunit of luteinizing hormone”. X-ray diffraction, 4 ligands (NAG, BMA, FUL), 2 pockets (best druggability 0.78). MolNFT v1 #159918 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6P57
- Type
- protein
- Length
- 224 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lutropin subunit beta
- UniProt
- P04651
- Ligands
- NAG, BMA, FUL, MAN
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lutropin subunit beta | protein | 106 | 0% helix, 40% strand | P04651 |
| B | Lutropin subunit beta | protein | 118 | 0% helix, 31% strand | P04651 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies
- FUL · beta-L-fucopyranose · sugar · 2 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 2 copies
- BOG · octyl beta-D-glucopyranoside · additive · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 829 | 0.78 | 0.81 | 82 | empty |
| 2 | 419 | 0.57 | 0.74 | 41 | empty |
Interfaces
1 interface between chains.
- A–B · 911 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04651
- Elsewhere: RCSB PDB 6P57 · PDBe 6P57 · UniProt P04651
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