MolNFT v1 · #159878 · protein
Yeast cytochrome C peroxidase (W191Y:L232H) in complex with iso-1 cytochrome C
6P42 · Cytochrome C peroxidase, mitochondrial: “Yeast cytochrome C peroxidase (W191Y:L232H) in complex with iso-1 cytochrome C”. X-ray diffraction, 1 ligand (HEM), 11 pockets (best druggability 0.81). MolNFT v1 #159878 on GenesisL1: 3D…
- PDB
- 6P42
- Type
- protein
- Length
- 794 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome C peroxidase, mitochondrial; Cytochrome C iso-1
- EC
- 1.11.1.5
- UniProt
- P00431, P00044
- Ligands
- HEM
- Pockets
- 11 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Cytochrome C peroxidase, mitochondrial (EC 1.11.1.5) | protein | 294 | 48% helix, 7% strand | P00431 |
| B, D | Cytochrome C iso-1 | protein | 103 | 37% helix, 0% strand | P00044 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 649 | 0.81 | 0.86 | 54 | empty |
| 2 | 370 | 0.81 | 0.90 | 44 | HEM |
| 3 | 218 | 0.80 | 0.93 | 35 | empty |
| 4 | 361 | 0.79 | 0.89 | 47 | HEM |
| 5 | 438 | 0.79 | 0.87 | 55 | HEM |
Interfaces
5 interfaces between chains.
- C–D · 697 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 644 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 458 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 246 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 202 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 cofactor (heme attachment).
Compared structures
- 6P42 · Yeast cytochrome c peroxidase (W191Y:L232H) in complex with iso-1 cytochrome c · the same entry in another collection · chain D against D, TM-score 1.00
- P00431 · AlphaFold monomer V2.0 prediction for cytochrome C peroxidase, mitochondrial (P00431) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P00044 · AlphaFold monomer V2.0 prediction for cytochrome C isoform 1 (P00044) · a predicted model of the same protein · chain D against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00431
- Every structure of UniProt P00044
- Elsewhere: RCSB PDB 6P42 · PDBe 6P42 · UniProt P00431 · UniProt P00044
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.