MolNFT v1 · #159866 · protein

Calpain-5 (CAPN5) protease core (pc)

6P3Q: “Calpain-5 (CAPN5) protease core (pc)”. X-ray diffraction, 6 pockets (best druggability 0.80). MolNFT v1 #159866 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6P3Q
Type: protein
Length: 690 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calpain-5
EC: 3.4.22.-
UniProt: O15484
Pockets: 6 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calpain-5 (EC 3.4.22.-)	protein	345	36% helix, 21% strand	O15484
B	Calpain-5 (EC 3.4.22.-)	protein	345	33% helix, 21% strand	O15484

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	970	0.80	0.81	76	empty
2	139	0.44	0.76	22	empty
3	135	0.40	0.75	21	empty
4	51	0.31	0.77	10	empty
5	66	0.30	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 717 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6P3Q · Calpain-5 (CAPN5) Protease Core (PC) · the same entry in another collection · chain B against B, TM-score 1.00
O15484 · AlphaFold monomer V2.0 prediction for calpain-5 (O15484) · a predicted model of the same protein · chain B against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15484
Elsewhere: RCSB PDB 6P3Q · PDBe 6P3Q · UniProt O15484

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