MolNFT v1 · #159726 · protein
Crystal structure of the phycocyanobilin-bound gaf domain from a cyanobacterial phytochrome
6OZA · Two-component sensor histidine kinase: “Crystal structure of the phycocyanobilin-bound gaf domain from a cyanobacterial phytochrome”. X-ray diffraction, 1 ligand (CYC), 4 pockets (best druggability 0.79). MolNFT v1 #159726 on…
- PDB
- 6OZA
- Type
- protein
- Length
- 549 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Two-component sensor histidine kinase
- UniProt
- Q8YTL8
- Ligands
- CYC
- Pockets
- 4 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Two-component sensor histidine kinase | protein | 183 | 40% helix, 27% strand | Q8YTL8 |
Ligands and binding sites
- CYC · Phycocyanobilin · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 608 | 0.79 | 0.84 | 56 | CYC |
| 2 | 600 | 0.78 | 0.83 | 55 | CYC |
| 3 | 612 | 0.77 | 0.83 | 52 | CYC |
| 4 | 50 | 0.29 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–C · 379 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 369 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 357 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 cofactor (phycocyanobilin attachment).
Compared structures
- 6OZA · Crystal structure of the phycocyanobilin-bound GAF domain from a cyanobacterial… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8YTL8
- Elsewhere: RCSB PDB 6OZA · PDBe 6OZA · UniProt Q8YTL8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.