MolNFT v1 · #159577 · protein

Crystal structure of the D380A/D478S variant of the myocilin olfactomedin domain

6OU0: “Crystal structure of the D380A/D478S variant of the myocilin olfactomedin domain”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #159577 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6OU0
Type: protein
Length: 244 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myocilin
UniProt: Q99972
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 1% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myocilin	protein	244	1% helix, 50% strand	Q99972

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.58	0.85	25	empty
2	92	0.55	0.85	28	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6OU0 · Crystal Structure of the D380A/D478S Variant of the Myocilin Olfactomedin Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q99972 · AlphaFold monomer V2.0 prediction for myocilin (Q99972) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99972
Elsewhere: RCSB PDB 6OU0 · PDBe 6OU0 · UniProt Q99972

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