MolNFT v1 · #159565 · protein
Crystal structure of an N-terminal fragment of cancer associated tropomyosin 3.1 (TPM3.1)
6OTN · Tropomyosin alpha-3 chain: “Crystal structure of an N-terminal fragment of cancer associated tropomyosin 3.1 (TPM3.1)”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.42). MolNFT v1 #159565 on GenesisL1: 3D…
- PDB
- 6OTN
- Type
- protein
- Length
- 282 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tropomyosin alpha-3 chain
- UniProt
- P06753
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.42
Structure
x-ray diffraction · 4 distinct chains · 96% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tropomyosin alpha-3 chain | protein | 69 | 97% helix, 0% strand | P06753 |
| B | Tropomyosin alpha-3 chain | protein | 67 | 94% helix, 0% strand | P06753 |
| C | Tropomyosin alpha-3 chain | protein | 75 | 96% helix, 0% strand | P06753 |
| D | Tropomyosin alpha-3 chain | protein | 71 | 96% helix, 0% strand | P06753 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 157 | 0.42 | 0.74 | 20 | empty |
| 2 | 56 | 0.31 | 0.76 | 15 | empty |
| 3 | 52 | 0.30 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- C–D · 2045 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1848 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1089 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 6OTN · Crystal Structure of an N-terminal Fragment of Cancer Associated Tropomyosin 3.1 (Tpm3.1) · the same entry in another collection · chain D against D, TM-score 1.00
- P06753 · AlphaFold monomer V2.0 prediction for tropomyosin alpha-3 chain (P06753) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06753
- Elsewhere: RCSB PDB 6OTN · PDBe 6OTN · UniProt P06753
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