MolNFT v1 · #159390 · protein

Crystal structure of bovine Fab nc-COW1

6OO0 · Nc-COW1 light chain: “Crystal structure of bovine Fab nc-COW1”. X-ray diffraction, 5 pockets (best druggability 0.51). MolNFT v1 #159390 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6OO0
Type: protein
Length: 483 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nc-COW1 light chain; Nc-COW1 heavy chain
Pockets: 5 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Nc-COW1 light chain	protein	215	7% helix, 50% strand	—
H	Nc-COW1 heavy chain	protein	268	10% helix, 47% strand	—

Ligands and binding sites

MPD · (4S)-2-methyl-2,4-pentanediol · additive · 3 copies · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	134	0.51	0.80	25	empty
2	305	0.50	0.73	36	empty
3	114	0.44	0.77	18	MPD
4	89	0.41	0.79	25	empty
5	72	0.29	0.73	19	empty

Interfaces

1 interface between chains.

L–H · 2239 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

6OO0 · Crystal structure of bovine Fab NC-Cow1 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6OO0 · PDBe 6OO0

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