MolNFT v1 · #159340 · protein

Human bmp chimera BV261

6OML · Bone morphogenetic protein 2 and bone morphogenetic protein…: “Human bmp chimera BV261”. X-ray diffraction, 3 ligands (NAG, MAN, BMA), 1 pocket (best druggability 0.51). MolNFT v1 #159340 on GenesisL1: 3D structure, binding sites…

PDB: 6OML
Type: protein
Length: 210 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bone morphogenetic protein 2 and bone morphogenetic protein 6
Ligands: NAG, MAN, BMA
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X, Y	Bone morphogenetic protein 2 and bone morphogenetic protein 6	protein	105	11% helix, 46% strand	—

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains Y, X
MAN · alpha-D-mannopyranose · sugar · 3 copies · chains Y
BMA · beta-D-mannopyranose · sugar · chains Y

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.51	0.78	34	empty

Interfaces

1 interface between chains.

X–Y · 1403 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

6OML · Human BMP chimera BV261 · the same entry in another collection · chain X against X, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6OML · PDBe 6OML

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