MolNFT v1 · #159339 · protein
Crystal structure of a glycylpeptide N-tetradecanoyltransferase (N- myristoyl transferase, nmt) from leishmania major friedlin bound to tetradecanoyl-CoA
6OMK: “Crystal structure of a glycylpeptide N-tetradecanoyltransferase (N- myristoyl transferase, nmt) from…”. X-ray diffraction, 2 ligands (MYA, ZN), 4 pockets (best druggability 0.80). MolNFT v1 #159339 on GenesisL1: 3D structure…
- PDB
- 6OMK
- Type
- protein
- Length
- 417 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycylpeptide N-tetradecanoyltransferase
- EC
- 2.3.1.97
- UniProt
- Q9GPZ4
- Ligands
- MYA, ZN
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) | protein | 417 | 31% helix, 26% strand | Q9GPZ4 |
Ligands and binding sites
- MYA · Tetradecanoyl-coa · ligand · chains A
- ZN · Zinc ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1121 | 0.80 | 0.81 | 87 | MYA |
| 2 | 83 | 0.75 | 0.97 | 26 | EDO |
| 3 | 61 | 0.51 | 0.87 | 20 | empty |
| 4 | 117 | 0.41 | 0.76 | 24 | empty |
Compared structures
- 6OMK · Crystal structure of a glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GPZ4
- Elsewhere: RCSB PDB 6OMK · PDBe 6OMK · UniProt Q9GPZ4
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