MolNFT v1 · #159127 · protein
Structure of the chlamydamonas reinhardtii camkii hub homology domain
6OF9: “Structure of the chlamydamonas reinhardtii camkii hub homology domain”. X-ray diffraction, 18 pockets (best druggability 0.59). MolNFT v1 #159127 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6OF9
- Type
- protein
- Length
- 1,195 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camkii hub
- UniProt
- A8IHL6
- Pockets
- 18 · best druggability 0.59
Structure
x-ray diffraction · 5 distinct chains · 26% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, B, C | Camkii hub | protein | 134 | 26% helix, 47% strand | A8IHL6 |
| D, A, G | Camkii hub | protein | 133 | 26% helix, 47% strand | A8IHL6 |
| F | Camkii hub | protein | 129 | 27% helix, 47% strand | A8IHL6 |
| H | Camkii hub | protein | 133 | 26% helix, 47% strand | A8IHL6 |
| I | Camkii hub | protein | 132 | 27% helix, 47% strand | A8IHL6 |
Pockets
18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 267 | 0.59 | 0.78 | 26 | empty |
| 2 | 308 | 0.59 | 0.77 | 27 | empty |
| 3 | 273 | 0.58 | 0.78 | 26 | empty |
| 4 | 260 | 0.58 | 0.78 | 26 | empty |
| 5 | 264 | 0.58 | 0.78 | 24 | empty |
Interfaces
18 interfaces between chains.
- G–H · 1212 Ų buried · 21 hydrogen bonds · protein-protein
- E–D · 1194 Ų buried · 18 hydrogen bonds · protein-protein
- C–F · 1177 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1177 Ų buried · 15 hydrogen bonds · protein-protein
- H–I · 699 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6OF9 · Structure of the Chlamydamonas reinhardtii CamKII hub homology domain · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8IHL6
- Elsewhere: RCSB PDB 6OF9 · PDBe 6OF9 · UniProt A8IHL6
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