MolNFT v1 · #159054 · protein

Crystal structure of human KCTD16 T1 domain

6OCR · BTB/POZ domain-containing protein KCTD16: “Crystal structure of human KCTD16 T1 domain”. X-ray diffraction, 14 pockets (best druggability 0.69). MolNFT v1 #159054 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6OCR
Type: protein
Length: 1,435 residues
Chains: 15
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BTB/POZ domain-containing protein KCTD16
UniProt: Q68DU8
Pockets: 14 · best druggability 0.69

Structure

x-ray diffraction · 12 distinct chains · 38% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, O	BTB/POZ domain-containing protein KCTD16	protein	95	39% helix, 17% strand	Q68DU8
D	BTB/POZ domain-containing protein KCTD16	protein	98	38% helix, 16% strand	Q68DU8
E	BTB/POZ domain-containing protein KCTD16	protein	102	38% helix, 16% strand	Q68DU8
F	BTB/POZ domain-containing protein KCTD16	protein	97	37% helix, 16% strand	Q68DU8
G	BTB/POZ domain-containing protein KCTD16	protein	96	38% helix, 17% strand	Q68DU8
H	BTB/POZ domain-containing protein KCTD16	protein	97	38% helix, 16% strand	Q68DU8
I	BTB/POZ domain-containing protein KCTD16	protein	93	34% helix, 17% strand	Q68DU8
J	BTB/POZ domain-containing protein KCTD16	protein	90	42% helix, 17% strand	Q68DU8
K	BTB/POZ domain-containing protein KCTD16	protein	94	37% helix, 17% strand	Q68DU8
L	BTB/POZ domain-containing protein KCTD16	protein	95	38% helix, 17% strand	Q68DU8
M	BTB/POZ domain-containing protein KCTD16	protein	97	37% helix, 16% strand	Q68DU8
N	BTB/POZ domain-containing protein KCTD16	protein	96	40% helix, 17% strand	Q68DU8

Pockets

14 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	775	0.69	0.76	68	empty
2	164	0.49	0.77	45	empty
3	131	0.49	0.79	23	empty
4	213	0.47	0.74	49	empty
5	123	0.47	0.78	20	empty

Interfaces

21 interfaces between chains.

I–J · 889 Å² buried · 22 hydrogen bonds · protein-protein
D–E · 879 Å² buried · 23 hydrogen bonds · protein-protein
B–C · 863 Å² buried · 23 hydrogen bonds · protein-protein
A–B · 863 Å² buried · 25 hydrogen bonds · protein-protein
C–D · 861 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

6OCR · Crystal structure of human KCTD16 T1 domain · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q68DU8
Elsewhere: RCSB PDB 6OCR · PDBe 6OCR · UniProt Q68DU8

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