MolNFT v1 · #158901 · protein
Trypanosoma cruzi EIF4E5 translation initiation factor in complex with cap-1
6O7Z · Putative eukaryotic translation initiation factor 4E type 5: “Trypanosoma cruzi EIF4E5 translation initiation factor in complex with cap-1”. X-ray diffraction, 2 ligands (LRP, SO4), 1 pocket (best druggability 0.46). MolNFT v1…
- PDB
- 6O7Z
- Type
- protein
- Length
- 181 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative eukaryotic translation initiation factor 4E type 5
- UniProt
- A0A2V2VRR6
- Ligands
- LRP, SO4
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative eukaryotic translation initiation factor 4E type 5 | protein | 181 | 32% helix, 29% strand | A0A2V2VRR6 |
Ligands and binding sites
- LRP · 2-amino-9-[(2R,3R,4S,5R)-5-({[(R)-{[(S)-{[(R)-({(2R,3R, 4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-3-hydroxy-4-methoxytetrahydrofuran-2-yl}methoxy)(hydroxy) phosphoryl]oxy}(hydroxy)phosphoryl]oxy}(hydroxy) phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium · ligand · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 112 | 0.46 | 0.79 | 28 | LRP |
Compared structures
- 6O7Z · Trypanosoma cruzi EIF4E5 translation initiation factor in complex with cap-1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2V2VRR6
- Elsewhere: RCSB PDB 6O7Z · PDBe 6O7Z · UniProt A0A2V2VRR6
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