MolNFT v1 · #158856 · protein

Structure of the regulator fasr from mycobacterium tuberculosis

6O6O · Tetr family transcriptional regulator: “Structure of the regulator fasr from mycobacterium tuberculosis”. X-ray diffraction, 1 ligand (MYR), 2 pockets (best druggability 0.83). MolNFT v1 #158856 on GenesisL1: 3D structure, binding…

PDB: 6O6O
Type: protein
Length: 374 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tetr family transcriptional regulator
UniProt: A0A045JBR0
Ligands: MYR
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tetr family transcriptional regulator	protein	190	79% helix, 0% strand	A0A045JBR0
B	Tetr family transcriptional regulator	protein	184	80% helix, 0% strand	A0A045JBR0

Ligands and binding sites

MYR · Myristic acid · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1017	0.83	0.83	100	MYR
2	61	0.33	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 1631 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

6O6O · Structure of the regulator FasR from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A045JBR0
Elsewhere: RCSB PDB 6O6O · PDBe 6O6O · UniProt A0A045JBR0

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