MolNFT v1 · #158791 · protein

The structure of human interleukin 11

6O4O · Interleukin-11: “The structure of human interleukin 11”. X-ray diffraction, 2 ligands (SO4, CL), 3 pockets (best druggability 0.65). MolNFT v1 #158791 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6O4O
Type: protein
Length: 169 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-11
UniProt: P20809
Ligands: SO4, CL
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-11	protein	169	68% helix, 0% strand	P20809

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.65	0.94	15	empty
2	126	0.36	0.73	24	empty
3	84	0.35	0.75	23	empty

Compared structures

6O4O · The structure of human interleukin 11 · the same entry in another collection · chain A against A, TM-score 1.00
P20809 · AlphaFold monomer V2.0 prediction for interleukin-11 (P20809) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20809
Elsewhere: RCSB PDB 6O4O · PDBe 6O4O · UniProt P20809

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