MolNFT v1 · #15875 · protein

Structure of the active ferm domain of ezrin

1NI2: “Structure of the active ferm domain of ezrin”. X-ray diffraction, 9 pockets (best druggability 0.60). MolNFT v1 #15875 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1NI2
Type: protein
Length: 592 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ezrin
UniProt: P15311
Pockets: 9 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ezrin	protein	296	36% helix, 24% strand	P15311

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	321	0.60	0.78	31	empty
2	313	0.60	0.78	30	empty
3	268	0.52	0.75	35	empty
4	158	0.45	0.75	22	empty
5	63	0.44	0.82	21	empty

Compared structures

1NI2 · Structure of the active FERM domain of Ezrin · the same entry in another collection · chain A against A, TM-score 1.00
P15311 · AlphaFold monomer V2.0 prediction for ezrin (P15311) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15311
Elsewhere: RCSB PDB 1NI2 · PDBe 1NI2 · UniProt P15311

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