MolNFT v1 · #158731 · protein
Crystal structure of the saraf luminal domain cys-lock mutant dimer
6O2W · Store-operated calcium entry-associated regulatory factor: “Crystal structure of the saraf luminal domain cys-lock mutant dimer”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #158731 on GenesisL1: 3D structure…
- PDB
- 6O2W
- Type
- protein
- Length
- 258 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Store-operated calcium entry-associated regulatory factor
- UniProt
- Q96BY9
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Store-operated calcium entry-associated regulatory factor | protein | 129 | 9% helix, 47% strand | Q96BY9 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 202 | 0.46 | 0.74 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 2418 Ų buried · 48 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6O2W · Crystal structure of the SARAF luminal domain Cys-lock mutant dimer · the same entry in another collection · chain A against A, TM-score 1.00
- Q96BY9 · AlphaFold monomer V2.0 prediction for store-operated calcium entry- associated regulatory… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96BY9
- Elsewhere: RCSB PDB 6O2W · PDBe 6O2W · UniProt Q96BY9
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