MolNFT v1 · #158725 · protein

Cdtb double heptamer short form modeled from cryo-EM MAP reconstructed using C1 symmetry

6O2O · ADP-ribosyltransferase binding component: “Cdtb double heptamer short form modeled from cryo-EM MAP reconstructed using C1 symmetry”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #158725 on GenesisL1: 3D…

PDB: 6O2O
Type: protein
Length: 9,218 residues
Chains: 14
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ADP-ribosyltransferase binding component
UniProt: A8DS70
Pockets: 20 · best druggability 0.88

Structure

electron microscopy · 3 distinct chains · 9% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, F, H, J, L	ADP-ribosyltransferase binding component	protein	659	8% helix, 37% strand	A8DS70
C, E, G, I, K, M	ADP-ribosyltransferase binding component	protein	658	9% helix, 29% strand	A8DS70
Z	ADP-ribosyltransferase binding component	protein	657	9% helix, 28% strand	A8DS70

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1102	0.88	0.90	146	empty
2	997	0.87	0.88	114	empty
3	876	0.84	0.86	84	empty
4	893	0.84	0.86	102	empty
5	988	0.84	0.85	106	empty

Interfaces

35 interfaces between chains.

J–L · 4136 Å² buried · 77 hydrogen bonds · protein-protein
A–B · 4104 Å² buried · 75 hydrogen bonds · protein-protein
A–L · 4103 Å² buried · 65 hydrogen bonds · protein-protein
H–J · 3991 Å² buried · 76 hydrogen bonds · protein-protein
F–H · 3983 Å² buried · 74 hydrogen bonds · protein-protein

Compared structures

6O2O · CDTb Double Heptamer Short Form Modeled from Cryo-EM Map Reconstructed using C1 Symmetry · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A8DS70
Elsewhere: RCSB PDB 6O2O · PDBe 6O2O · UniProt A8DS70

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