MolNFT v1 · #158691 · protein + RNA
Architectural principles for HFQ/CRC-mediated regulation of gene expression hfq-crc-amie 2:3:2 complex
6O1L · Catabolite repression control protein: “Architectural principles for HFQ/CRC-mediated regulation of gene expression hfq-crc-amie 2:3:2 complex”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #158691 on…
- PDB
- 6O1L
- Type
- protein + RNA
- Length
- 1,615 residues
- Chains
- 17
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catabolite repression control protein; RNA-binding protein hfq; RNA (5'…
- EC
- 3.1.11.2
- UniProt
- Q51380, Q9HUM0
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 7 distinct chains · 22% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, R | Catabolite repression control protein (EC 3.1.11.2) | protein | 262 | 26% helix, 24% strand | Q51380 |
| C, K | RNA-binding protein hfq | protein | 65 | 18% helix, 46% strand | Q9HUM0 |
| D, E, H, I, M | RNA-binding protein hfq | protein | 67 | 19% helix, 45% strand | Q9HUM0 |
| F, J | RNA-binding protein hfq | protein | 65 | 20% helix, 48% strand | Q9HUM0 |
| G, N | RNA-binding protein hfq | protein | 66 | 15% helix, 45% strand | Q9HUM0 |
| L | RNA-binding protein hfq | protein | 66 | 20% helix, 47% strand | Q9HUM0 |
| O, P | RNA (5'- R(*AP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3') | rna | 18 | — | — |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 762 | 0.79 | 0.83 | 90 | empty |
| 2 | 763 | 0.79 | 0.83 | 73 | empty |
| 3 | 807 | 0.74 | 0.79 | 63 | empty |
| 4 | 722 | 0.74 | 0.80 | 48 | empty |
| 5 | 618 | 0.73 | 0.80 | 58 | empty |
Interfaces
41 interfaces between chains.
- I–N · 872 Ų buried · 13 hydrogen bonds · protein-protein
- L–M · 832 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 827 Ų buried · 11 hydrogen bonds · protein-protein
- F–H · 825 Ų buried · 11 hydrogen bonds · protein-protein
- D–E · 819 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6O1L · Architectural principles for Hfq/Crc-mediated regulation of gene expression Hfq-Crc-amiE… · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q51380
- Every structure of UniProt Q9HUM0
- Elsewhere: RCSB PDB 6O1L · PDBe 6O1L · UniProt Q51380 · UniProt Q9HUM0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.