MolNFT v1 · #158678 · protein

Unliganded alpha-L-fucosidase alfc from lactobacillus casei

6O18: “Unliganded alpha-L-fucosidase alfc from lactobacillus casei”. X-ray diffraction, 13 pockets (best druggability 0.71). MolNFT v1 #158678 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6O18
Type: protein
Length: 1,300 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alfc
UniProt: K0NB39
Pockets: 13 · best druggability 0.71

Structure

x-ray diffraction · 4 distinct chains · 38% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alfc	protein	329	37% helix, 14% strand	K0NB39
B	Alfc	protein	323	38% helix, 15% strand	K0NB39
C	Alfc	protein	326	38% helix, 14% strand	K0NB39
D	Alfc	protein	322	38% helix, 15% strand	K0NB39

Pockets

13 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.71	0.97	23	empty
2	54	0.70	0.97	15	empty
3	261	0.58	0.78	32	empty
4	239	0.57	0.78	33	empty
5	224	0.57	0.79	27	empty

Interfaces

3 interfaces between chains.

B–D · 1284 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 1272 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 356 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6O18 · Unliganded alpha-L-fucosidase AlfC from Lactobacillus casei · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt K0NB39
Elsewhere: RCSB PDB 6O18 · PDBe 6O18 · UniProt K0NB39

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