MolNFT v1 · #158640 · protein

Extracellular factors prime enterovirus particles for uncoating

6O06 · VP1: “Extracellular factors prime enterovirus particles for uncoating”. Electron microscopy, 9 pockets (best druggability 0.62). MolNFT v1 #158640 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6O06
Type: protein
Length: 691 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VP1; VP2; VP3
UniProt: O91734
Pockets: 9 · best druggability 0.62

Structure

electron microscopy · 3 distinct chains · 5% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	VP1	protein	220	5% helix, 36% strand	O91734
B	VP2	protein	247	6% helix, 35% strand	O91734
C	VP3	protein	224	5% helix, 33% strand	O91734

Pockets

9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	375	0.62	0.78	57	empty
2	117	0.44	0.77	25	empty
3	69	0.44	0.81	15	empty
4	114	0.39	0.75	21	empty
5	88	0.38	0.77	18	empty

Interfaces

3 interfaces between chains.

A–C · 3023 Å² buried · 32 hydrogen bonds · protein-protein
A–B · 1740 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 1540 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6O06 · Extracellular factors prime enterovirus particles for uncoating · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O91734
Elsewhere: RCSB PDB 6O06 · PDBe 6O06 · UniProt O91734

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.