MolNFT v1 · #158549 · protein
Crystal structure of mouse REC114 pH domain in complex with ANKRD31 C terminus
6NXF · Meiotic recombination protein REC114: “Crystal structure of mouse REC114 pH domain in complex with ANKRD31 C terminus”. X-ray diffraction, 3 pockets (best druggability 0.54). MolNFT v1 #158549 on GenesisL1: 3D structure, binding…
- PDB
- 6NXF
- Type
- protein
- Length
- 339 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Meiotic recombination protein REC114; Ankyrin repeat domain 31
- UniProt
- Q9CWH4, A0A140LI88
- Pockets
- 3 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 22% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Meiotic recombination protein REC114 | protein | 125 | 13% helix, 55% strand | Q9CWH4 |
| B | Meiotic recombination protein REC114 | protein | 120 | 13% helix, 56% strand | Q9CWH4 |
| V | Ankyrin repeat domain 31 | protein | 48 | 44% helix, 15% strand | A0A140LI88 |
| U | Ankyrin repeat domain 31 | protein | 46 | 46% helix, 7% strand | A0A140LI88 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.54 | 0.76 | 33 | empty |
| 2 | 91 | 0.45 | 0.80 | 20 | empty |
| 3 | 119 | 0.43 | 0.77 | 20 | empty |
Interfaces
6 interfaces between chains.
- B–V · 1925 Ų buried · 23 hydrogen bonds · protein-protein
- A–U · 1883 Ų buried · 16 hydrogen bonds · protein-protein
- A–V · 632 Ų buried · 13 hydrogen bonds · protein-protein
- V–U · 150 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 55 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 6NXF · Crystal structure of mouse REC114 PH domain in complex with ANKRD31 C terminus · the same entry in another collection · chain A against A, TM-score 1.00
- Q9CWH4 · AlphaFold monomer V2.0 prediction for meiotic recombination protein REC114 (Q9CWH4) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9CWH4
- Every structure of UniProt A0A140LI88
- Elsewhere: RCSB PDB 6NXF · PDBe 6NXF · UniProt Q9CWH4 · UniProt A0A140LI88
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.