MolNFT v1 · #158530 · protein

Rorgamma ligand binding domain

6NWU · Nuclear receptor ror-gamma: “Rorgamma ligand binding domain”. X-ray diffraction, 1 ligand (L7J), 4 pockets (best druggability 0.82). MolNFT v1 #158530 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6NWU
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear receptor ror-gamma
UniProt: P51449
Ligands: L7J
Pockets: 4 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear receptor ror-gamma	protein	259	64% helix, 4% strand	P51449

Ligands and binding sites

L7J · 6-[(3,5-dichloropyridin-4-yl)methoxy]-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2,3-dihydro-1H-indole · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	397	0.82	0.90	38	L7J
2	191	0.52	0.77	18	empty
3	77	0.38	0.77	17	empty
4	82	0.37	0.76	14	empty

Compared structures

6NWU · RORgamma Ligand Binding Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51449
Elsewhere: RCSB PDB 6NWU · PDBe 6NWU · UniProt P51449

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