MolNFT v1 · #158470 · protein + RNA
Ebola virus nucleoprotein - RNA complex
6NUT: “Ebola virus nucleoprotein - RNA complex”. Electron microscopy, 5 pockets (best druggability 0.56). MolNFT v1 #158470 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NUT
- Type
- protein + RNA
- Length
- 385 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein; RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3')
- UniProt
- P18272
- Pockets
- 5 · best druggability 0.56
Structure
electron microscopy · 2 distinct chains · 65% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoprotein | protein | 379 | 65% helix, 5% strand | P18272 |
| D | RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3') | rna | 6 | — | — |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.56 | 0.90 | 19 | empty |
| 2 | 180 | 0.53 | 0.79 | 29 | empty |
| 3 | 121 | 0.52 | 0.82 | 19 | empty |
| 4 | 234 | 0.49 | 0.74 | 37 | empty |
| 5 | 50 | 0.27 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–D · 938 Ų buried · 19 hydrogen bonds · protein-nucleic
Compared structures
- 6NUT · Ebola virus nucleoprotein - RNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18272
- Elsewhere: RCSB PDB 6NUT · PDBe 6NUT · UniProt P18272
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