MolNFT v1 · #158439 · protein
Sftsv L endonuclease domain
6NTV · RNA polymerase: “Sftsv L endonuclease domain”. X-ray diffraction, 12 pockets (best druggability 0.73). MolNFT v1 #158439 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6NTV
- Type
- protein
- Length
- 678 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase
- UniProt
- A0A2U8JAJ4
- Pockets
- 12 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | RNA polymerase | protein | 226 | 35% helix, 22% strand | A0A2U8JAJ4 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 537 | 0.73 | 0.82 | 60 | empty |
| 2 | 290 | 0.73 | 0.86 | 49 | empty |
| 3 | 364 | 0.64 | 0.79 | 37 | empty |
| 4 | 283 | 0.54 | 0.76 | 48 | empty |
| 5 | 52 | 0.43 | 0.84 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1280 Ų buried · 25 hydrogen bonds · protein-protein
- A–C · 1273 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 188 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 6NTV · SFTSV L endonuclease domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2U8JAJ4
- Elsewhere: RCSB PDB 6NTV · PDBe 6NTV · UniProt A0A2U8JAJ4
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